منابع مشابه
Neurogenesis and affective disorders.
The neurogenesis hypothesis of depression was originally formed upon the demonstration that stress impacts levels of adult neurogenesis in the hippocampus. Since then much work has established that newborn neurons in the dentate gyrus are required for mediating some of the beneficial effects of antidepressant treatment. Recent studies combining behavioral, molecular and electrophysiological app...
متن کاملSeasonality in affective disorders.
Humans retain neurobiological responses to circadian day-night cycles and seasonal changes in daylength in spite of a life-style usually independent of dawn-dusk signals. Seasonality has been documented in many functions, from mood to hormones to gene expression. Research on seasonal affective disorder initiated the first use of timed bright light as therapy, a treatment since extended to non-s...
متن کاملAffective Disorders: Oneormore
of affective disorders (bipolar affective disorder, major depressive disorder and anxiety states) result from multiple genes that confer a susceptibility or liability to develop the disorder when other (environmental) risk factors are also present. In general, bipolar affective disorder has been found to have the highest heritability (i.e. the proportion of variance explained by additive geneti...
متن کاملGenetics of affective disorders.
Despite substantial evidence for heritability in affective disorders the contributing genes have proven elusive. Here we discuss the genetic epidemiology of depression, as well as methodological issues and results from molecular genetic studies. There has been rapid advances in genetics, genomics and statistical modelling, facilitating the search for molecular mechanisms underlying affective di...
متن کاملMetabolic imbalance in affective disorders
INTRODUCTION Depression is the most frequent mental disorder encountered in all medical services. Multiple studies have shown that depression may predict the onset of different conditions, such as heart disease, diabetes, stroke and many other. The relation between depression and diabetes is still unclear. MATERIALS AND METHODS In this study we evaluated patients with both major depressive di...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1984
ISSN: 0022-3050
DOI: 10.1136/jnnp.47.1.117-a